There is a low number of female student’s enrollment in Computer Science field in many countries. Much effort has been done to motivate females to study computer science, but it is still not enough. Serious games are effective tools for learning, thus can be used to motivate females to study technical subjects such as computer science. However, gender preferences affect the motivation to play specific types of digital games, but only a few studies have attempted to design games specifically for females. In addition, most games with computer science content do not appeal to teenage girls, and failed to explain how the social and cultural content of the game described the game experience of female players. However, studies have discovered the impact of engagement in the game based learning environment., In this paper, we discuss female’s preferences in digital games and the social and cultural factors that influence female’s engagement in Information and Communication Technology or specifically computer science studies. We propose a gender-based serious game engagement’s model for teaching computer science.